Mobile element scanning (ME-Scan) by targeted high-throughput sequencing

  title={Mobile element scanning (ME-Scan) by targeted high-throughput sequencing},
  author={David J. Witherspoon and Jinchuan Xing and Yuhua Zhang and W. Scott Watkins and Mark A. Batzer and Lynn B. Jorde},
  booktitle={BMC Genomics},
Mobile elements (MEs) are diverse, common and dynamic inhabitants of nearly all genomes. ME transposition generates a steady stream of polymorphic genetic markers, deleterious and adaptive mutations, and substrates for further genomic rearrangements. Research on the impacts, population dynamics, and evolution of MEs is constrained by the difficulty of ascertaining rare polymorphic ME insertions that occur against a large background of pre-existing fixed elements and then genotyping them in many… CONTINUE READING