Mobile Regulatory Cassettes Mediate Modular Shuffling in T4-Type Phage Genomes

@inproceedings{Arbiol2010MobileRC,
  title={Mobile Regulatory Cassettes Mediate Modular Shuffling in T4-Type
                    Phage Genomes},
  author={Christine Arbiol and Andr{\'e} M. Comeau and Mariam Kutateladze and Revaz Adamia and Henrik Krisch},
  booktitle={Genome biology and evolution},
  year={2010}
}
Coliphage phi1, which was isolated for phage therapy in the Republic of Georgia, is closely related to the T-like myovirus RB49. The approximately 275 open reading frames encoded by each phage have an average level of amino acid identity of 95.8%. RB49 lacks 7 phi1 genes while 10 phi1 genes are missing from RB49. Most of these unique genes encode functions without known homologs. Many of the insertion, deletion, and replacement events that distinguish the two phages are in the hyperplastic… CONTINUE READING
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