Mobile Elements: Drivers of Genome Evolution

@article{Kazazian2004MobileED,
  title={Mobile Elements: Drivers of Genome Evolution},
  author={Haig H. Kazazian},
  journal={Science},
  year={2004},
  volume={303},
  pages={1626 - 1632}
}
Mobile elements within genomes have driven genome evolution in diverse ways. Particularly in plants and mammals, retrotransposons have accumulated to constitute a large fraction of the genome and have shaped both genes and the entire genome. Although the host can often control their numbers, massive expansions of retrotransposons have been tolerated during evolution. Now mobile elements are becoming useful tools for learning more about genome evolution and gene function. 
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References

SHOWING 1-10 OF 77 REFERENCES
Fruit flies and humans respond differently to retrotransposons.
The outs and ins of transposition: from Mu to Kangaroo
Transposons are ubiquitous in prokaryotic and eukaryotic organisms and are major determinants of genome structure. Transposition — the movement of discrete segments of DNA without a requirement for…
Nonmethylated transposable elements and methylated genes in a chordate genome.
TLDR
The genome of the invertebrate chordate Ciona intestinalis was found to be a stable mosaic of methylated and nonmethylated domains, which are incompatible with the genome defense model, which proposes that DNA methylation in animals is primarily targeted to endogenous transposable elements.
Nested Retrotransposons in the Intergenic Regions of the Maize Genome
TLDR
Diagnostic sequencing indicated that a 280-kilobase region containing the maize Adh1-F and u22 genes is composed primarily of retrotransposons inserted within each other, and ten retroelement families were discovered.
Integration of the yeast retrotransposon Ty1 is targeted to regions upstream of genes transcribed by RNA polymerase III.
TLDR
Ty1 has evolved a powerful targeting mechanism, requiring Pol III transcription to integrate its DNA at very specific locations within the yeast genome.
Retroelements containing introns in diverse invertebrate taxa
We report that two structurally similar transposable elements containing reverse transcriptase (RT), Penelope in Drosophila virilis and Athena in bdelloid rotifers, have proliferated as copies…
Diversity of retrotransposable elements in compact pufferfish genomes.
Alu repeats and human genomic diversity
During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different…
Biology of mammalian L1 retrotransposons.
TLDR
L1 retrotransposons comprise 17% of the human genome and may find other practical applications in gene discovery following insertional mutagenesis in mice and in the delivery of therapeutic genes.
Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres.
TLDR
Analysis of HeT-A and TART is providing insight into the evolution of chromosomes, retrotransposons, and retroviruses, and recent studies show that Retrotransposon telomeres constitute a robust system for maintaining chromosome ends.
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