Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

@inproceedings{Noritake2009MobileDP,
  title={Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95},
  author={Jun Noritake and Yuko Fukata and Tsuyoshi Iwanaga and Naoki Hosomi and Ryouhei Tsutsumi and Naoto Matsuda and Hideki Tani and Hiroko Iwanari and Yasuhiro Mochizuki and Tatsuhiko Kodama and Yoshiharu Matsuura and David S. Bredt and Takao Hamakubo and Masaki Fukata},
  booktitle={The Journal of cell biology},
  year={2009}
}
Protein palmitoylation is the most common posttranslational lipid modification; its reversibility mediates protein shuttling between intracellular compartments. A large family of DHHC (Asp-His-His-Cys) proteins has emerged as protein palmitoyl acyltransferases (PATs). However, mechanisms that regulate these PATs in a physiological context remain unknown. In this study, we efficiently monitored the dynamic palmitate cycling on synaptic scaffold PSD-95. We found that blocking synaptic activity… CONTINUE READING
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