Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila.

@article{Ho2010MobAT,
  title={Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila.},
  author={Li-Lun Ho and Xiaomu Wei and Takeshi Shimizu and Zhi-chun Lai},
  journal={Developmental biology},
  year={2010},
  volume={337 2},
  pages={274-83}
}
Growth inhibition mediated by Hippo (Hpo) signaling is essential for tissue growth and organ size control in Drosophila. However, the cellular mechanism by which the core components like Mob as tumor suppressor (Mats) and Warts (Wts) protein kinase are activated is poorly understood. In this work, we found that the endogenous Mats is located at the plasma membrane in developing tissues. Membrane targeting constitutively activates Mats to promote apoptosis and reduce cell proliferation, which… CONTINUE READING

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