MntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.

@article{Pandey2015MntRRv2788AT,
  title={MntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.},
  author={Ruchi Pandey and Riccardo Russo and Saleena S Ghanny and Xiaojuan Huang and John D. Helmann and Galaxia M Rodriguez},
  journal={Molecular microbiology},
  year={2015},
  volume={98 6},
  pages={1168-83}
}
The pathogenic mycobacterium Mycobacterium tuberculosis encodes two members of the DtxR/MntR family of metalloregulators, IdeR and SirR. IdeR represses gene expression in response to ferrous iron, and we here demonstrate that SirR (Rv2788), although also annotated as an iron-dependent repressor, functions instead as a manganese-dependent transcriptional repressor and is therefore renamed MntR. MntR regulates transporters that promote manganese import and genes that respond to metal ion… CONTINUE READING
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