MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese.

@article{KehlFie2013MntABCAM,
  title={MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese.},
  author={Thomas E Kehl-Fie and Yaofang Zhang and Jessica L Moore and Allison J. Farrand and M. Indriati Hood and Subodh G Rathi and Walter J Chazin and Richard M Caprioli and Eric P Skaar},
  journal={Infection and immunity},
  year={2013},
  volume={81 9},
  pages={3395-405}
}
During infection, vertebrates limit access to manganese and zinc, starving invading pathogens, such as Staphylococcus aureus, of these essential metals in a process termed "nutritional immunity." The manganese and zinc binding protein calprotectin is a key component of the nutrient-withholding response, and mice lacking this protein do not sequester manganese from S. aureus liver abscesses. One potential mechanism utilized by S. aureus to minimize host-imposed manganese and zinc starvation is… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…