Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.

@article{Harris2003MnsodOE,
  title={Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.},
  author={Nicholas John Harris and V{\'i}tor Costa and M W Maclean and Mehdi Mollapour and Pedro Moradas-Ferreira and Peter W Piper},
  journal={Free radical biology & medicine},
  year={2003},
  volume={34 12},
  pages={1599-606}
}
Studies in Drosophila and Caenorhabditis elegans have shown increased longevity with the increased free radical scavenging that accompanies overexpression of oxidant-scavenging enzymes. This study used yeast, another model for aging research, to probe the effects of overexpressing the major activity protecting against superoxide generated by the mitochondrial respiratory chain. Manganese superoxide dismutase (MnSOD) overexpression increased chronological life span (optimized survival of… CONTINUE READING

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