Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.

Abstract

Angiotensin II (Ang II) stimulates protein synthesis in vascular smooth muscle cells (VSMCs), possibly secondary to regulatory changes at the initiation of mRNA translation. Mitogen-activated protein (MAP) kinase signal-integrating kinase-1 (Mnk1), a substrate of ERK and p38 MAP kinase, phosphorylates eukaryotic initiation factor 4E (eIF4E), an important… (More)

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@article{Ishida2003Mnk1IR, title={Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells.}, author={Mari Ishida and Takafumi Ishida and Hidekatsu Nakashima and Narimasa Miho and Kiyoshi Miyagawa and Kazuaki Chayama and Tetsuya Oshima and Masayuki Kambe and Masao Yoshizumi}, journal={Circulation research}, year={2003}, volume={93 12}, pages={1218-24} }