MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signaling in cancer

  title={MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signaling in cancer},
  author={Peter C. Hart and Mao Mao and Andre Luelsdorf Pimenta de Abreu and Kristine Ansenberger-Fricano and Dede N. Ekoue and Douglas Ganini and Andr{\'e} A. Kajdacsy-Balla and Alan M Diamond and Richard D Minshall and M{\'a}rcia E Lopes Consolaro and Janine H Santos and Marcelo Gialluisi Bonini},
  booktitle={Nature communications},
Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that governs the types of reactive oxygen species egressing from the organelle to affect cellular signalling. Here we demonstrate that MnSOD upregulation in cancer cells establishes a steady flow of H2O2 originating from mitochondria that sustains AMP-activated kinase (AMPK) activation and the metabolic shift to glycolysis. Restricting MnSOD expression or inhibiting AMPK suppresses the metabolic switch and dampens the… CONTINUE READING


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