MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.

@article{Miller2010MnSODPA,
  title={MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.},
  author={Jordan D. Miller and V. Peotta and Y. Chu and R. Weiss and K. Zimmerman and R. Brooks and D. Heistad},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={298 5},
  pages={
          H1600-7
        }
}
Endothelial function is impaired by oxidative stress in chronic heart failure (HF). Mechanisms that protect against increases in oxidative stress in HF are not clear. The goal of this study was to determine whether manganese superoxide dismutase (MnSOD) plays a key role in protecting against endothelial dysfunction in HF. Endothelial function and gene expression were examined in aorta from wild-type mice (MnSOD(+/+)) and mice deficient in MnSOD (MnSOD(+/-)) 12 wk after ligation of the left… Expand
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