Mn2+-dependent protein phosphatase 1 enhances protein kinase A-induced Ca2+ desensitisation in skinned murine myocardium.

@article{Neulen2007Mn2dependentPP,
  title={Mn2+-dependent protein phosphatase 1 enhances protein kinase A-induced Ca2+ desensitisation in skinned murine myocardium.},
  author={Axel Neulen and Natascha Blaudeck and Stefan Zittrich and Doris Metzler and Gabriele Pfitzer and Robert Stehle},
  journal={Cardiovascular research},
  year={2007},
  volume={74 1},
  pages={
          124-32
        }
}
OBJECTIVE Phosphorylation of proteins in cardiac myofilaments is a major determinant in the regulation of the Ca(2+) sensitivity of contraction. Whereas most reports have focused on effects of phosphorylation, little is known about reverse effects of dephosphorylation in skinned myocardium. Here we studied the effect of the Mn(2+)-dependent catalytic subunit of protein phosphatase 1 (PP1c-alpha) on the Ca(2+) regulation of contraction. In particular, we tested the hypothesis that… CONTINUE READING
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