Mn(II) mediated degradation of artemisinin based on Fe3O4@MnSiO3-FA nanospheres for cancer therapy in vivo.

@article{Chen2015MnIIMD,
  title={Mn(II) mediated degradation of artemisinin based on Fe3O4@MnSiO3-FA nanospheres for cancer therapy in vivo.},
  author={Jian Chen and Weijie Zhang and Min Zhang and Zhen R. Guo and Hai-bao Wang and Mengni He and Pengping Xu and Jiajia Zhou and Zhenbang Liu and Qian-wang Chen},
  journal={Nanoscale},
  year={2015},
  volume={7 29},
  pages={12542-51}
}
Artemisinin (ART) is a natural drug with potent anticancer activities related with Fe(2+) mediated cleavage of the endoperoxide bridge in ART. Herein, we reported that Mn(2+) could substitute for Fe(2+) to react with ART and generate toxic products, inducing a much higher anticancer efficiency. On this basis, we prepared pH-responsive Fe3O4@MnSiO3-FA nanospheres which can efficiently deliver hydrophobic ART into tumors in mice models. Mn(2+) was released in acidic tumor environments and… CONTINUE READING
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