Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?

@article{Meroni2000MlxAN,
  title={Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?},
  author={Germana Meroni and Stefano Cairo and Giuseppe Merla and Silvia Messali and Roger Brent and Andrea Ballabio and Alexandre Reymond},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={3266-3277}
}
The Myc proto-oncogene family members have been identified as the cellular homologs of the transforming oncogene of avian retroviruses. They encode central regulators of mammalian cell proliferation and apoptosis, and they associate with the bHLHZip protein Max to bind specific DNA sequences and regulate the expression of genes important for cell cycle progression. The other family members, Mad1, Mxi1, Mad3, Mad4 and Rox (Mnt) antagonize their activities. The Mads and Rox compete with Myc in… CONTINUE READING