Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation

Abstract

Central precocious puberty (CPP) is attributed to the disorder of some trigger factors those can activate the hypothalamic-pituitary-gonadal axis controlled by GnRH neurons. Many recent studies reveal one of those trigger factors, Makorin ring finger protein 3 (Mkrn3), whose loss-of-function mutations are implicated in CPP. Although Mkrn3 contained zinc… (More)
DOI: 10.18632/oncotarget.19347

Topics

  • Presentations referencing similar topics