Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons.

@article{Kristiansen2010Mkp1IA,
  title={Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons.},
  author={Mark Kristiansen and Rosie Hughes and Pritika H. Patel and Thomas S Jacques and A R Clark and Jonathan Ham},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 32},
  pages={
          10820-32
        }
}
Developing sympathetic neurons depend on NGF for survival. When sympathetic neurons are deprived of NGF in vitro, a well documented series of events, including c-Jun N-terminal kinase (JNK) pathway activation, release of cytochrome c from the mitochondria, and caspase activation, culminates in the death of the neuron by apoptosis within 24-48 h. This process requires de novo gene expression, suggesting that increased expression of specific genes activates the cell death program. Using rat gene… CONTINUE READING
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