Mkl transcription cofactors regulate structural plasticity in hippocampal neurons.

@article{OSullivan2010MklTC,
  title={Mkl transcription cofactors regulate structural plasticity in hippocampal neurons.},
  author={Niamh C. O'Sullivan and Mark Pickering and Danika Di Giacomo and Jennifer S Loscher and K. P. S. J. Murphy},
  journal={Cerebral cortex},
  year={2010},
  volume={20 8},
  pages={1915-25}
}
Expressed throughout the central nervous system, the myocardin-related, megakaryoblastic acute leukemia 1 and 2 (Mkl1/2) are transcriptional cofactors that can be found tethered in the cytoplasm to monomeric actin but on synaptic activation translocate to the nucleus and associate with transcription factors such as serum response factor (SRF) to regulate expression of structural genes. This implies a potential role for Mkls in linking synaptic activity, through gene-expression control, to… CONTINUE READING
13 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

EBImage: image processing and image analysis toolkit for R

  • O Sklyar, G Pau, M Smith, W. Huber
  • Available from: URL http:// www.bioconductor.org…
  • 2009
2 Excerpts

Similar Papers

Loading similar papers…