Mizoribine and mycophenolate mofetil.

  title={Mizoribine and mycophenolate mofetil.},
  author={Hiroko Ishikawa},
  journal={Current medicinal chemistry},
  volume={6 7},
Both mizoribine (MZR) and mycophenolate mofetil (MMF) are immunosuppressive agents that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH. MZR is a nucleoside of the imidazole class, isolated from the culture medium of the mold Eupenicillium brefeldianum M-2166. Although this compound has been found to have weak antimicrobial activity against Candida albicans, it has proved ineffective against experimental candidiasis. Unlike azathioprine, this compound is not taken… CONTINUE READING
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