Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products.

@article{Orton2014MixtureEA,
  title={Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products.},
  author={Frances Orton and Sibylle Ermler and Subramaniam Kugathas and Erika Rosivatz and Martin Scholze and Andreas Kortenkamp},
  journal={Toxicology and applied pharmacology},
  year={2014},
  volume={278 3},
  pages={201-8}
}
Many xenobiotics have been identified as in vitro androgen receptor (AR) antagonists, but information about their ability to produce combined effects at low concentrations is missing. Such data can reveal whether joint effects at the receptor are induced at low levels and may support the prioritisation of in vivo evaluations and provide orientations for the grouping of anti-androgens in cumulative risk assessment. Combinations of 30 AR antagonists from a wide range of sources and exposure… CONTINUE READING
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