Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells

  title={Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells},
  author={Željko S. Ži{\vz}ak and Zorica D. Jurani{\'c} and Dejan M Opsenica and Bogdan A {\vS}olaja},
  journal={Investigational New Drugs},
In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological… CONTINUE READING
3 Citations
28 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 28 references

Structure–activity relationship study of steroidal 1,2,4,5-tetraoxane animalarials using computational procedures

  • AK Bhattacharjee, KA Carvalho, D Opsenica, BA Solaja
  • J Serb Chem Soc 70:329–345
  • 2005

Similar Papers

Loading similar papers…