Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function.

  title={Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function.},
  author={Sashwati Roy and Haytham Elgharably and Mithun Sinha and Kasturi Ganesh and Sarah B. Chaney and Ethan E. Mann and Christina Miller and Savita Khanna and Valerie K. Bergdall and Heather M. Powell and Charles H Cook and Gayle M. Gordillo and Daniel J Wozniak and Chandan K. Sen},
  journal={The Journal of pathology},
  volume={233 4},
In chronic wounds, biofilm infects host tissue for extended periods of time. This work establishes the first chronic preclinical model of wound biofilm infection aimed at addressing the long-term host response. Although biofilm-infected wounds did not show marked differences in wound closure, the repaired skin demonstrated compromised barrier function. This observation is clinically significant, because it leads to the notion that even if a biofilm infected wound is closed, as observed visually… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 31 extracted citations

Similar Papers

Loading similar papers…