Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervix.


A mixed papillary adenocarcinoma and transitional cell carcinoma (MAcTcc) was discovered in the uterine cervix of a 38-year-old woman. A condylomatous papillary lesion was found in the uterine cervix during a colposcopic study and histopathological examination showed that the tumor was composed of two different neoplastic subtypes. One was an adenocarcinoma (AC) component showing papillary and tubular structure with endocervical and intestinal differentiation; the other was a transitional cell carcinoma (TCC) component showing papillary excrescence mimicking papillary TCC of urothelial origin. To characterize the tumor, an immunohistochemical study of cytokeratins (CK) was performed. The AC component showed immunoreactivities similar to conventional adenocarcinomas: positive immunoreactivity of low-molecular-weight cytokeratins 7, 8 and 19, and negative immunoreactivity of CK20 and high-molecular-weight cytokeratin (34betaE12). The lower epithelial layer of the TCC component showed different immunoreactivity, but the superficial epithelial layer had similar immunohistochemical findings to the AC component. These findings indicate that the TCC component had the cellular character of AC rather than that of TCC or squamous cell carcinomas. This is thought to be the first report of a MAcTcc of the uterine cervix.

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@article{Murata2004MixedPA, title={Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervix.}, author={Shin-ichi Murata and Kazuyuki Miyata and Koji Takaishi and Kunio Mochizuki and Tadao Nakazawa and Tetsuo Kondo and Nobuki Nakamura and Ryohei Katoh}, journal={Pathology international}, year={2004}, volume={54 1}, pages={63-6} }