Mixed pH-Sensitive Polymeric Micelles for Combination Drug Delivery

Abstract

To prepare mixed polymeric micelles that can carry two different drugs, doxorubicin (DOX) and 17-hydroxyethylamino-17-demethoxygeldanamycin (GDM-OH), for combination cancer chemotherapy. The pH-sensitive micelles were prepared from poly(ethylene glycol)-poly(aspartate hydrazide) block copolymers to which either DOX or GDM-OH is conjugated through acid… (More)
DOI: 10.1007/s11095-010-0234-3

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