Mixed lymphocyte reaction blocking factors (MLR-Bf) as potential biomarker for indication and efficacy of paternal lymphocyte immunization in recurrent spontaneous abortion

@article{Khonina2013MixedLR,
  title={Mixed lymphocyte reaction blocking factors (MLR-Bf) as potential biomarker for indication and efficacy of paternal lymphocyte immunization in recurrent spontaneous abortion},
  author={Nataliya A. Khonina and Esteban Broitman and Ekaterina Ya. Shevela and Nataliya M Pasman and Elena Rem Chernykh},
  journal={Archives of Gynecology and Obstetrics},
  year={2013},
  volume={288},
  pages={933-937}
}
The majority of cases of unexplained recurrent spontaneous abortion (RSA) remains unclear and is found to be associated with alloimmune antibodies termed as mixed lymphocyte reaction blocking factor (MLR-Bf). The decreased production of MLR-Bf may play major role in the immunologic failure of pregnancy and can lead to abortion. The present study was aimed at evaluating MLR-Bf as potential biomarker of indication and the efficacy of immunotherapy with paternal lymphocytes (LIT) in women with RSA… CONTINUE READING

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