Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.

@article{Silva2005MixedLK,
  title={Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.},
  author={Robert M Silva and C-Y. Kuan and Pasko Raki{\'c} and Robert E Burke},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2005},
  volume={20 6},
  pages={653-64}
}
There is growing evidence that the molecular pathways of programmed cell death play a role in neurodegenerative disease, including Parkinson's disease, so there has been increased interest in them as therapeutic targets for the development of neuroprotective strategies. One pathway of cell death that has attracted particular attention is the mixed lineage kinase (MLK) -c-jun N-terminal kinase (JNK) signaling cascade, which leads to the phosphorylation and activation of the transcription factor… CONTINUE READING

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