Mixed lineage kinase activity of indolocarbazole analogues.

  title={Mixed lineage kinase activity of indolocarbazole analogues.},
  author={Chikara Murakata and Masami Kaneko and George W Gessner and Thelma S. Angeles and Mark A. Ator and Teresa M O'Kane and Beth Ann W McKenna and Beth Ann Thomas and Joanne R. Mathiasen and Michael S. Saporito and Donna Bozyczko-Coyne and Robert L. Hudkins},
  journal={Bioorganic & medicinal chemistry letters},
  volume={12 2},
The MLK1-3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (16, CEP-11004/KT-8138) is reported.