Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.

@article{Ibrahim2016MixedLK,
  title={Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.},
  author={Samar H Ibrahim and Petra Hirsova and Kyoko Tomita and Steven F. Bronk and Nathan W. Werneburg and S. A. Harrison and Val S Goodfellow and Harmeet Malhi and Gregory J. Gores},
  journal={Hepatology},
  year={2016},
  volume={63 3},
  pages={731-44}
}
UNLABELLED Mixed lineage kinase 3 (MLK3) deficiency reduces macrophage-associated inflammation in a murine model of nonalcoholic steatohepatitis (NASH). However, the mechanistic links between MLK3 activation in hepatocytes and macrophage-driven inflammation in NASH are uncharted. Herein, we report that MLK3 mediates the release of (C-X-C motif) ligand 10 (CXCL10)-laden extracellular vesicles (EVs) from lipotoxic hepatocytes, which induce macrophage chemotaxis. Primary mouse hepatocytes (PMHs… CONTINUE READING
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