Mixed infection and clonal representativeness of a single sputum sample in tuberculosis patients from a penitentiary hospital in Georgia

@article{Shamputa2006MixedIA,
  title={Mixed infection and clonal representativeness of a single sputum sample in tuberculosis patients from a penitentiary hospital in Georgia},
  author={Isdore Chola Shamputa and Levan Jugheli and Nikoloz Sadradze and Eve Willery and Françoise Portaels and Philip Supply and Leen Rigouts},
  journal={Respiratory Research},
  year={2006},
  volume={7},
  pages={99 - 99}
}
BACKGROUND Studies on recurrent tuberculosis (TB), TB molecular epidemiology and drug susceptibility testing rely on the analysis of one Mycobacterium tuberculosis isolate from a single sputum sample collected at different disease episodes. This scheme rests on the postulate that a culture of one sputum sample is homogeneous and representative of the total bacillary population in a patient. METHODS We systematically analysed several pre-treatment isolates from each of 199 smear-positive male… CONTINUE READING

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