Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity.

@article{Moeini2017MixedHC,
  title={Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity.},
  author={Agrin Moeini and Daniela Sia and Zhongyang Zhang and Gen{\'i}s Campreci{\'o}s and Ashley E Stueck and Hui Dong and R Montal and Laura Torrens and Iris Martinez-Quetglas and Maria Isabel Fiel and Ke Hao and Augusto Villanueva and Swan N. Thung and Myron Eliot Schwartz and Josep M Llovet},
  journal={Journal of hepatology},
  year={2017},
  volume={66 5},
  pages={952-961}
}
BACKGROUND & AIMS Mixed hepatocellular cholangiocarcinoma (HCC-CCA) is a rare and poorly understood type of primary liver cancer. We aimed to perform a comprehensive molecular characterization of this malignancy. METHODS Gene expression profiling, DNA copy number detection, and exome sequencing using formalin-fixed samples from 18 patients with mixed HCC-CCA were performed, encompassing the whole histological spectrum of the disease. Comparative genomic analysis was carried out, using… CONTINUE READING
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