Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line.

@article{Grant1988MixedFO,
  title={Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line.},
  author={Mary Helen Grant and Susan J. Duthie and Albert G. Gray and Mary D. Burke},
  journal={Biochemical pharmacology},
  year={1988},
  volume={37 21},
  pages={
          4111-6
        }
}
In cultured human hepatoma cells phenolphthalein glucuronidation was increased 3-fold by 2 mM phenobarbitone (PB) in the culture medium but not by 25 microM benz(a)anthracene (BA), while 1-naphthol glucuronidation was not increased by either PB or BA. Ethoxyresorufin O-deethylation (EROD) was increased 15-fold by BA but not by PB, while the O-dealkylations of pentoxyresorufin (PROD) and benzyloxyresorufin (BROD) were increased by either PB or BA. The BROD activity increased by BA was sensitive… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS