Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency.

Abstract

Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a "shock and kill" strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA ("shock"), treatment with SAHA did not result in a reduction of reservoir size ("kill"). We therefore utilized a combined analysis of effects of SAHA on the… (More)
DOI: 10.1016/j.antiviral.2015.09.002

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Cite this paper

@article{White2015MixedEO, title={Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency.}, author={Cory White and Harvey E Johnston and Bastiaan Moesker and A. G. Manousopoulou and David M Margolis and Douglas D. Richman and Celsa A Spina and Spiros D. Garbis and Christopher H. Woelk and Nadejda S Beliakova-Bethell}, journal={Antiviral research}, year={2015}, volume={123}, pages={78-85} }