Mixed-effects logistic approach for association following linkage scan for complex disorders.

@article{Xu2007MixedeffectsLA,
  title={Mixed-effects logistic approach for association following linkage scan for complex disorders.},
  author={H J Xu and Sanjay Shete},
  journal={Annals of human genetics},
  year={2007},
  volume={71 Pt 2},
  pages={230-7}
}
An association study to identify possible causal single nucleotide polymorphisms following linkage scanning is a popular approach for the genetic dissection of complex disorders. However, in association studies cases and controls are assumed to be independent, i.e., genetically unrelated. Choosing a single affected individual per family is statistically… CONTINUE READING