Mixed connective tissue disease

  title={Mixed connective tissue disease},
  author={Patrick J. W. Venables},
  pages={132 - 137}
  • P. Venables
  • Published 1 March 2006
  • Medicine, Biology
  • Lupus
Mixed connective tissue disease (MCTD) was first described in 1972 as a disease syndrome with overlapping features of systemic sclerosis, systemic lupus erythematosus (SLE) and polymyositis associated with antibodies to RNAse sensitive extractable nuclear antigen. When the antigen was subsequently characterized as polypeptides on the U1 ribonuclear protein component of the splicesosome (U1RNP), MCTD became the first rheumatic disease syndrome to be defined by a serologic test. Clinical features… 

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  • 1992
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