Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemia

@article{Zetterquist2000MixedCI,
  title={Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemia},
  author={Henrik Zetterquist and J. -E. Mattsson and Mehmet Uzunel and Ingrid N{\"a}sman-Bj{\"o}rk and Petter Svenberg and L Tammik and Gholamreza Bayat and Jacek H Winiarski and Olle Ringd{\'e}n},
  journal={Bone Marrow Transplantation},
  year={2000},
  volume={25},
  pages={843-851}
}
One of the major problems after allogeneic bone marrow transplantation (BMT) is a high frequency of leukemia relapse. We have prospectively studied the presence of donor- and recipient-derived chimeric cells in bone marrow recipients with pre-B cell acute lymphoblastic leukemia (pre-B-ALL). The chimeric status of BMT recipients was compared to minimal residual disease (MRD) detection by analysis of immunoglobulin heavy chain (IgH) and T cell receptor (TcR) genes. Post-transplant blood and bone… CONTINUE READING