Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy.

@article{Hayashi2003MixedCF,
  title={Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy.},
  author={Satoshi Hayashi and Osheiza Abdulmalik and William H. Peranteau and Shuichi Ashizuka and Cesare Campagnoli and Qiukan Chen and Kazumi Horiuchi and Toshio Asakura and Alan W. Flake},
  journal={Experimental hematology},
  year={2003},
  volume={31 2},
  pages={176-84}
}
OBJECTIVE Mixed hematopoietic chimerism after bone marrow transplantation can provide effective treatment for beta-thalassemia because of the selective advantage that exists for donor erythropoiesis. In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve mixed hematopoietic chimerism, particularly when a selective advantage exists for donor cells. To investigate the biology of IUHSCTx in hemoglobinopathies, we performed fully allogeneic IUHSCTx in murine models of beta… CONTINUE READING
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