Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation.

@article{Millan2002MixedCA,
  title={Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation.},
  author={Maria T. Millan and Judith A Shizuru and Petra F. Hoffmann and Sussan Dejbakhsh-Jones and John D Scandling and Frank C. Grumet and Jane C Tan and Ordonez Salvatierra and Richard T Hoppe and Samuel Strober},
  journal={Transplantation},
  year={2002},
  volume={73 9},
  pages={
          1386-91
        }
}
BACKGROUND Rodents and dogs conditioned with total-lymphoid irradiation (TLI), with or without antithymocyte globulin (ATG), have been shown to develop mixed chimerism and immune tolerance without graft-versus-host disease (GVHD) after the infusion of major histocompatability complex (MHC)-mismatched donor bone marrow cells given alone or in combination with an organ allograft. METHODS Four human leukocyte antigen (HLA)-mismatched recipients of living donor kidney transplants were conditioned… CONTINUE READING
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