Mixed allogeneic chimerism in the rat. Donor-specific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts.

@article{Colson1995MixedAC,
  title={Mixed allogeneic chimerism in the rat. Donor-specific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts.},
  author={Yolonda L Colson and K S Zadach and Mike Nalesnik and Suzanne T. Ildstad},
  journal={Transplantation},
  year={1995},
  volume={60 9},
  pages={971-80}
}
Graft loss secondary to chronic rejection remains a major source of morbidity and mortality in solid organ transplantation. Mixed chimerism has been suggested as one potential approach to overcome this limitation. Until now, whether long-term tolerance for primarily vascularized allografts can be achieved with mixed chimerism has not been adequately assessed due to technical limitations in the mouse and the inability to establish a reliable model of mixed chimerism in the rat. We now report… CONTINUE READING

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