Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function.

  title={Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with $\beta$ Cell Function.},
  author={Hartmut Ruetten and Mathias Gebauer and Ralph H. Raymond and Roberto A Calle and Claudio Cobelli and Atalanta Ghosh and R. Paul Robertson and Sudha S Shankar and Myrlene A Staten and Darko Stefanovski and Adrian Vella and Kathryn Wright and David A. Fryburg},
  journal={Metabolic syndrome and related disorders},
  volume={16 8},
BACKGROUND The aims of this study were to 1. define the responses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon, and peptide YY (PYY) to an oral meal and to intravenous L-arginine; and 2. examine correlation of enteroendocrine hormones with insulin secretion. We hypothesized a relationship between circulating incretin concentrations and insulin secretion. METHODS Subjects with normal glucose tolerance (NGT, n = 23), prediabetes (PDM, n = 17… Expand
2 Citations
Effects of mixed meal tolerance test on gastric emptying, glucose and lipid homeostasis in obese nonhuman primates
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Stimulus-Secretion Coupling in Beta-Cells: From Basic to Bedside.
  • M. Islam
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  • Advances in experimental medicine and biology
  • 2020
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Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series
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Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
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Defects in GLP-1 response to an oral challenge do not play a significant role in the pathogenesis of prediabetes.
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