Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of β-Cell Function in Therapeutic Trials in Type 1 Diabetes

@article{Greenbaum2008MixedMealTT,
  title={Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of β-Cell Function in Therapeutic Trials in Type 1 Diabetes  },
  author={Carla J Greenbaum and Thomas Mandrup-Poulsen and Paula Friedenberg McGee and Tadej Battelino and Burkhart Haastert and Johnny Ludvigsson and Paolo Pozzilli and John M Lachin and Hubert Kolb},
  journal={Diabetes Care},
  year={2008},
  volume={31},
  pages={1966 - 1971}
}
OBJECTIVE Beta-cell function in type 1 diabetes clinical trials is commonly measured by C-peptide response to a secretagogue in either a mixed-meal tolerance test (MMTT) or a glucagon stimulation test (GST). The Type 1 Diabetes TrialNet Research Group and the European C-peptide Trial (ECPT) Study Group conducted parallel randomized studies to compare the sensitivity, reproducibility, and tolerability of these procedures. RESEARCH DESIGN AND METHODS In randomized sequences, 148 TrialNet… CONTINUE READING