Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

@article{Sun2012MixedLK,
  title={Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase},
  author={Liming Sun and Haibin Wang and Zhigao Wang and Sudan He and She Chen and Daohong Liao and Lai Wang and Jiacong Yan and Weilong Liu and Xiaoguang Lei and Xiaodong Wang},
  journal={Cell},
  year={2012},
  volume={148},
  pages={213-227}
}
The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety of physiological and pathological conditions, including development, tissue damage response, and antiviral immunity. Here, we report the identification of a small molecule called (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide--hereafter referred to as necrosulfonamide… CONTINUE READING
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