Mixed Cocaine Agonist/Antagonist Properties of (+)-Methyl 4β-(4-Chlorophenyl)-1-methylpiperidine-3α-carboxylate, a Piperidine-Based Analog of Cocaine

  title={Mixed Cocaine Agonist/Antagonist Properties of (+)-Methyl 4$\beta$-(4-Chlorophenyl)-1-methylpiperidine-3$\alpha$-carboxylate, a Piperidine-Based Analog of Cocaine},
  author={Alan P. Kozikowski and Kenneth M. Johnson and Olivier Deschaux and Bidhan C. Bandyopadhyay and Gian Luca Araldi and Gilberto N. Carmona and Patrik Munzar and Miles P. Smith and Robert L. Balster and Patrick M Beardsley and Srihari R. Tella},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={143 - 150}
The present study investigated the pharmacological properties of a piperidine-based novel cocaine analog, namely, (+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylic acid [(+)-CPCA]. Like cocaine, (+)-CPCA inhibited rat synaptosomal dopamine and norepinephrine uptake with high affinity, but was 33-fold less potent than cocaine in inhibiting serotonin uptake. Like cocaine, (+)-CPCA is a locomotor stimulant, although it was less potent and efficacious than cocaine. Importantly… 

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