Mix-and-diffuse serial synchrotron crystallography

  title={Mix-and-diffuse serial synchrotron crystallography},
  author={Kenneth R Beyerlein and Dennis Dierksmeyer and Valerio Mariani and Manuela Kuhn and Iosifina Sarrou and Angelica Ottaviano and Salah Awel and Juraj Knoska and Silje Fuglerud and Olof J{\"o}nsson and Stephan Stern and Max O Wiedorn and Oleksandr Yefanov and Luigi Adriano and Richard Bean and Anja Burkhardt and Pontus Fischer and Michael J. Heymann and Daniel A Horke and Katharina E J Jungnickel and Elena Kovaleva and Olga Lorbeer and Markus Metz and Jan Timo Meyer and Andrew Morgan and Kanupriya Pande and Saravanan Panneerselvam and Carolin Seuring and Aleksandra Tolstikova and Julia Lieske and Steve Aplin and Manfred Roessle and Thomas A. White and Henry N. Chapman and Alke Meents and Dominik Oberthuer},
Unravelling the interaction of biological macromolecules with ligands and substrates at high spatial and temporal resolution remains a major challenge in structural biology. The development of serial crystallography methods at X-ray free-electron lasers and subsequently at synchrotron light sources allows new approaches to tackle this challenge. Here, a new polyimide tape drive designed for mix-and-diffuse serial crystallography experiments is reported. The structure of lysozyme bound by the… CONTINUE READING
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