Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation.

@article{GrandeAllen2005MitralVS,
  title={Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation.},
  author={K. Jane Grande-Allen and J. Edward Barber and Katrina M. Klatka and Penny L. Houghtaling and Ivan Vesely and Christine Schomisch Moravec and P E Mccarthy},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2005},
  volume={130 3},
  pages={
          783-90
        }
}
OBJECTIVE Mitral regurgitation is a complication for many patients with congestive heart failure. Although this regurgitation is considered purely functional, we hypothesize that the alterations in cardiac geometry and function induce dysfunctional remodeling of the mitral valve, which can be demonstrated by alterations in the material behavior of the leaflets and chordae. METHODS Mitral leaflets and chordae from 23 valves from transplant recipient hearts (11 with dilated and 12 with ischemic… CONTINUE READING

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