Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis

@article{Nalliah2018MitralVP,
  title={Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis},
  author={Chrishan Joseph Nalliah and Rajiv Mahajan and Adrian D. Elliott and Haris M. Haqqani and Dennis H. Lau and Jitendra Vohra and Joseph B. Morton and Christopher Semsarian and Thomas H. Marwick and Jonathan M. Kalman and Prashanthan Sanders},
  journal={Heart},
  year={2018},
  volume={105},
  pages={144 - 151}
}
Objectives Mitral valve prolapse (MVP) is commonly observed as a benign finding. However, the literature suggests that it may be associated with sudden cardiac death (SCD). We performed a meta-analysis and systematic review to determine the: (1) prevalence of MVP in the general population; (2) prevalence of MVP in all SCD and unexplained SCD; (3) incidence of SCD in MVP and (4) risk factors for SCD. Methods The English medical literature was searched for: (1) MVP community prevalence; (2) MVP… 

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
TTE red flags that could identify MVP patients at high risk to develop complex arrhythmias as supported by the corresponding findings of LGE‐CMR and anatomy studies are described.

Presentation and Outcome of Arrhythmic Mitral Valve Prolapse.

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TLDR
Mitral valve prolapse caused an ischaemic ST-T segment depression in a young woman indicating a high risk of sudden cardiac death and need for immediate drug therapy, according to Russian recommendations on treatment of connective tissue dysplasia.

Ventricular arrhythmias in mitral valve prolapse: new explanations for an old problem

TLDR
Nearly 60 years after the first description by Barlow, mitral valve prolapse still remains a diagnosis of great interest and intense controversy, driven by the high prevalence and general lack of knowledge of the pathophysiological basis underlying most of these associations.
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TLDR
Clinical and echocardiographic characteristics allow separation of the majority of patients with excellent prognosis from subsets of patients displaying, during follow-up, high morbidity or even excess mortality as direct a consequence of MVP.

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TLDR
Comparison-enhanced cardiac magnetic resonance may help to identify in vivo this concealed substrate for risk stratification of ventricular electric instability, an underestimated cause of arrhythmic SCD in young adult women.

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TLDR
Parental MVP and NDMs are associated with increased prevalence of offspring MVP, highlighting the genetic substrate of MVP and the potential clinical significance of NDMs in the community.

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TLDR
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TLDR
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