Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis

  title={Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis},
  author={Chrishan Joseph Nalliah and Rajiv Mahajan and Adrian D. Elliott and Haris M. Haqqani and Dennis H. Lau and Jitendra Vohra and Joseph B. Morton and Christopher Semsarian and Thomas H. Marwick and Jonathan M. Kalman and Prashanthan Sanders},
  pages={144 - 151}
Objectives Mitral valve prolapse (MVP) is commonly observed as a benign finding. However, the literature suggests that it may be associated with sudden cardiac death (SCD). We performed a meta-analysis and systematic review to determine the: (1) prevalence of MVP in the general population; (2) prevalence of MVP in all SCD and unexplained SCD; (3) incidence of SCD in MVP and (4) risk factors for SCD. Methods The English medical literature was searched for: (1) MVP community prevalence; (2) MVP… 

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Nearly 60 years after the first description by Barlow, mitral valve prolapse still remains a diagnosis of great interest and intense controversy, driven by the high prevalence and general lack of knowledge of the pathophysiological basis underlying most of these associations.



Natural History of Asymptomatic Mitral Valve Prolapse in the Community

Clinical and echocardiographic characteristics allow separation of the majority of patients with excellent prognosis from subsets of patients displaying, during follow-up, high morbidity or even excess mortality as direct a consequence of MVP.

Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death

Comparison-enhanced cardiac magnetic resonance may help to identify in vivo this concealed substrate for risk stratification of ventricular electric instability, an underestimated cause of arrhythmic SCD in young adult women.

Familial Clustering of Mitral Valve Prolapse in the Community

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Bileaflet MVP syndrome is characterized by fascicular and papillary muscle VE that triggers ventricular fibrillation that improves symptoms and reduces appropriate implantable cardioverter defibrillator shocks.

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