Mitral Valve Prolapse With a Late-Systolic Regurgitant Murmur May Be Associated With Significant Hemodynamic Consequences

@article{Ahmed2009MitralVP,
  title={Mitral Valve Prolapse With a Late-Systolic Regurgitant Murmur May Be Associated With Significant Hemodynamic Consequences},
  author={Mustafa Iltimas Ahmed and Thriveni Sanagala and Thomas S. Denney and Seidu Inusah and David C McGiffin and Donald Knowlan and Robert A. O'rourke and Louis J. Dell’Italia},
  journal={The American Journal of the Medical Sciences},
  year={2009},
  volume={338},
  pages={113-115}
}
The late-systolic murmur of mitral regurgitation (MR) in degenerative mitral valve disease is widely believed to represent regurgitation of a degree that is not associated with hemodynamic significance. However, the extent of left ventricular (LV) remodeling associated with the late-systolic murmur has not been systematically assessed. Accordingly, we studied 82 patients sent for evaluation of at least moderate isolated MR by echocardiography/Doppler examination. All patients had a physical… 

Mitral Valve Prolapse With Mid-Late Systolic Mitral Regurgitation: Pitfalls of Evaluation and Clinical Outcome Compared With Holosystolic Regurgitation

TLDR
MR of mitral valve prolapse that is purely mid-late systolic causes more benign consequences and outcomes than holosystolic MR, requiring less mitral surgery.

Improved Right Ventricular Performance with Increased Tricuspid Annular Excursion in Athlete’s Heart

TLDR
Right ventricular adaptation to chronic volume overload was evaluated in MTH and MR and normal controls together with interventricular septal remodeling and tricuspid annulus (TA) motion, finding increased TA kinetics allows for improved RV performance in M TH.

Mitral Valve Prolapse

TLDR
The auscultation features, maneuvers for altering the intensity and timing of the click, audio of this murmur, risk factors, annular calcification and myxomatous degeneration are discussed.

References

SHOWING 1-10 OF 18 REFERENCES

Echocardiographic markers for mitral valve surgery to preserve left ventricular performance in mitral regurgitation.

TLDR
Echocardiographic measures, particularly an end-systolic dimension of >/=40 mm, may be useful for identifying patients with MR before surgery with early, occult LV contractile dysfunction in whom MV surgery may be recommended to preserve LV systolic performance.

Significance and prognosis of an isolated late systolic murmur: a 9- to 22-yearyearfollow-up.

TLDR
Patients were excluded from the series if there were more than minimal left atrial or left ventricular enlargement on x-ray, an abnormal electrocardiogram apart from multiple ventricular ectopics and succeeding flat T waves, or a history of chest pain closely associated with exertion.

Preoperative left ventricular end systolic dimension as a predictor of postoperative ventricular dysfunction in children with mitral regurgitation

TLDR
The records of children who had MV surgery for severe MR were analysed to evaluate the change of LV function and to identify any potential risk variable for late postoperative LV dysfunction.

Wall stress and patterns of hypertrophy in the human left ventricle.

TLDR
The hypothesis that hypertrophy develops to normalize systolic but not diastolic wall stress is suggested, and it is proposed that increased syStolic tension development by myocardial fibers results in fiber thickening just sufficient to return the systolics stress (force per unit cross-sectional area) to normal.

Bedside diagnosis of systolic murmurs.

TLDR
Although no single maneuver is 100 percent accurate in diagnosing the cause of a systolic murmur, its origin can be determined accurately at the bedside by observation of the response to a combination of maneuvers.

Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation.

TLDR
A positive correlation between LV diastolic wall stress and increased ACE activity with increased ANG II stores is demonstrated, suggesting that mechanical wall stress activated intracardiac ACE.