Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

@article{Morningstar2021MitralVP,
  title={Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis},
  author={Jordan E. Morningstar and Cortney Gensemer and Reece Moore and Diana B Fulmer and Tyler C Beck and Christina Wang and Kelsey S. Moore and Lilong Guo and Franz Sieg and Yasufumi Nagata and Philippe B. Bertrand and Ricardo A. Spampinato and Janiece Glover and Steven Poelzing and Robert G. Gourdie and Kelsey Watts and William J. Richardson and Robert A. Levine and Michael A. Borger and Russell A Norris},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year={2021},
  volume={10}
}
Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP. Methods and Results We performed histopathologic analysis of left ventricular… 

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References

SHOWING 1-10 OF 49 REFERENCES

Diffuse myocardial fibrosis in patients with mitral valve prolapse and ventricular arrhythmia

TLDR
Diffuse interstitial derangement is linked to subclinical systolic dysfunction, and may contribute to ComVA in MVP-related mitral regurgitation, even in the absence of focal fibrosis.

Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse

TLDR
STE-derived mechanical dispersion may help identify MVP patients at higher arrhythmic risk and was the only significant predictor of arrhythmmic risk on multivariate analysis.

Mutations in DCHS1 Cause Mitral Valve Prolapse

TLDR
A missense mutation in the DCHS1 gene, the human homologue of the Drosophila cell polarity gene dachsous (ds), that segregates with MVP in the family is reported, supporting these processes as aetiological underpinnings for the disease.

The Mitral Annulus Disjunction Arrhythmic Syndrome.

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

TLDR
The first risk loci for MVP are identified and new mechanisms involved in mitral valve regurgitation are suggested, including tensin 1, a focal adhesion protein involved in cytoskeleton organization, which is shown during valve morphogenesis.

Mitral valve disease—morphology and mechanisms

TLDR
The approach, which bridges clinicians and basic scientists, enables the correlation of observed disease with cellular and molecular mechanisms, leading to the discovery of new opportunities for improving the natural history of mitral valve disease.

Increased Infiltration of Extra-Cardiac Cells in Myxomatous Valve Disease

TLDR
In vivo experiments demonstrate increased infiltration of hematopoietic-derived cells and macrophages in adolescent Filamin-A conditional knockout mice and an increase in Erk activity, which localizes to regions of MMP2 expression, suggesting immune cell targeting and/or suppression of pErk activities may represent an effective therapeutic option for mitral valve prolapse patients.