Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

  title={Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis},
  author={Jordan E. Morningstar and Cortney Gensemer and Reece Moore and Diana B Fulmer and Tyler C Beck and Christina Wang and Kelsey S. Moore and Lilong Guo and Franz Sieg and Yasufumi Nagata and Philippe B. Bertrand and Ricardo A. Spampinato and Janiece Glover and Steven Poelzing and Robert G. Gourdie and Kelsey Watts and William J. Richardson and Robert A. Levine and Michael A. Borger and Russell A Norris},
  journal={Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP. Methods and Results We performed histopathologic analysis of left ventricular… 

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