Mitoxantrone treatment in multiple sclerosis: a 5‐year clinical and MRI follow‐up

@article{Buttinelli2007MitoxantroneTI,
  title={Mitoxantrone treatment in multiple sclerosis: a 5‐year clinical and MRI follow‐up},
  author={Carla Buttinelli and Alessandro Clemenzi and Giovanna Borriello and F G Denaro and Carlo Pozzilli and Cesare Fieschi},
  journal={European Journal of Neurology},
  year={2007},
  volume={14}
}
Mitoxantrone (MTX) is an antineoplastic agent approved for treatment of secondary progressive and rapidly worsening relapsing‐remitting multiple sclerosis (MS). We designed a longitudinal open‐label prospective study to evaluate the efficacy and toxicity of MTX over a 2‐year treatment period with a further 3‐year follow‐up. Fifty consecutive MS patients were included and received MTX intravenously (8 mg/m2 every 2 months for a total of 12 infusions). Efficacy was assessed clinically and by… 

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