Mitoxantrone metabolism in the isolated perfused rat liver

  title={Mitoxantrone metabolism in the isolated perfused rat liver},
  author={Gerhard Ehninger and Barbara Proksch and Franz Hartmann and H. Gaertner and Klaus Wilms},
  journal={Cancer Chemotherapy and Pharmacology},
The hepatobiliary pharmacokinetics of mitoxantrone, a new anthracenedione derivative, was studied in the isolated perfused rat liver. Mitoxantrone was administered in doses of 0.2 and 0.4 mg/kg body weight. Multiple bile samples were obtained for 4 hours. Mitoxantrone and three metabolites were separated by high-performance thin-layer chromatography (HPTLC) and measured at 610 nm. Following 0.2 mg mitroxantrone/kg body wt, 25.8%±2.6% of the administered dose was excreted in the bile during 4 h… CONTINUE READING