Mitoxantrone-induced suicidal erythrocyte death.

@article{Arnold2014MitoxantroneinducedSE,
  title={Mitoxantrone-induced suicidal erythrocyte death.},
  author={Markus Arnold and Rosi Bissinger and Florian Lang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2014},
  volume={34 5},
  pages={1756-67}
}
BACKGROUND/AIMS Mitoxantrone, a cytotoxic drug used for the treatment of malignancy and multiple sclerosis, is at least in part effective by triggering apoptosis. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a type of suicidal cell death. Hallmarks of eryptosis are cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signalling involved in eryptosis include Ca(2+)-entry, ceramide formation and oxidative… CONTINUE READING

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Reproduced with the permission

  • AG S.Karger, Basel
  • 2014

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