Mitoxantrone-induced suicidal erythrocyte death.

  title={Mitoxantrone-induced suicidal erythrocyte death.},
  author={Markus Arnold and Rosi Bissinger and Florian Lang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={34 5},
BACKGROUND/AIMS Mitoxantrone, a cytotoxic drug used for the treatment of malignancy and multiple sclerosis, is at least in part effective by triggering apoptosis. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a type of suicidal cell death. Hallmarks of eryptosis are cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signalling involved in eryptosis include Ca(2+)-entry, ceramide formation and oxidative… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 64 extracted citations


Publications referenced by this paper.
Showing 1-10 of 108 references

Reproduced with the permission

  • AG S.Karger, Basel
  • 2014

Similar Papers

Loading similar papers…