Mitoxantrone, More than Just Another Topoisomerase II Poison

@article{Evison2016MitoxantroneMT,
  title={Mitoxantrone, More than Just Another Topoisomerase II Poison},
  author={Benny J. Evison and Brad E. Sleebs and Keith Geoffrey Watson and Don R. Phillips and Suzanne M. Cutts},
  journal={Medicinal Research Reviews},
  year={2016},
  volume={36}
}
Mitoxantrone is a synthetic anthracenedione originally developed to improve the therapeutic profile of the anthracyclines and is commonly applied in the treatment of breast and prostate cancers, lymphomas, and leukemias. A comprehensive overview of the drug's molecular, biochemical, and cellular pharmacology is presented here, beginning with the cardiotoxic nature of its predecessor doxorubicin and how these properties shaped the pharmacology of mitoxantrone itself. Although mitoxantrone is… 
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